Maybe Ange's style is too demanding, and that it's all speed and no brains. Whereas maybe other top managers might not need to play 90 minutes of non-stop speed, making up for it with adaptability and tactics (rather than the accusation against Ange that he was a one-trick pony, easily found out by top calibre coaches in the Premier League).
I believe, as many others in the Media do as well, that two seasons in a row with most of his 1st team injured was not "bad luck" but a direct consequences of Ange's methods used at the highest Premier League level. Because in the Premier League, where the other Premier League teams are already so fast compared to lower level football, it means that Ange-ball at Premier League level has to be insanely fast (i.e. stupidly fast). Hence, not sustainable over the course of a Premier League season.